| AAAAI/ACAAI surveillance study |
| Grade 1 → Mild systemic reactions: |
| Generalized urticaria and/or upper respiratory symptoms (eg, itching of the palate and throat, sneezing) |
| Grade 2 → Moderate systemic reactions: |
| Asthma (eg, PEFR falls 20 to 40%) with or without generalized urticaria, upper respiratory symptoms, or abdominal symptoms (nausea, cramping) |
| Grade 3 → Severe life-threatening anaphylaxis: |
| Severe airway compromise due to severe bronchospasm (eg, PEFR falls more than 40%) or upper airway obstruction with stridor, and/or hypotension (with or without loss of consciousness) |
