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Course of chronic HBV infection

Course of chronic HBV infection
The course of chronic HBV infection is considered to consist of four phases: immune tolerance, immune clearance (HBeAg-positive chronic hepatitis), inactive carrier, and reactivation (HBeAg-negative chronic hepatitis), although not all patients go through every phase.
HBeAg, hepatitis B e antigen; anti-HBe, antibody to HBeAg; HBV, hepatitis B virus; ALT, alanine aminotransferase.
Reproduced with permission from: Yim HJ, Lok AS. Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005. Hepatology 2006; 43:S173. Copyright © 2006 John Wiley & Sons, Inc.
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