| Drug | Peak serum concentration | Elimination half-life | Metabolism | Active metabolites | Protein binding, percent |
| Fluoxetine | 6-8 hours | Parent: 2-6 days | Liver (2D6, 2C9, 3A4) | Norfluoxetine | 94.5 |
| Metabolite: 7-10 days | |||||
| Sertraline | 4.5-8.4 hours | 26 hours | Liver (2C9, 2D6, 3A4) | Desmethylsertraline (weakly active) | 98 |
| Paroxetine | 5.2 hours | 21 hours | Liver (2D6) | None | 95 |
| Fluvoxamine | 3-8 hours | 15.6 hours | Liver (1A2, 2D6) | None | 80 |
| Citalopram | 4 hours | 35 hours | Liver (3A4, 2D6, 2C19) | Desmethylcitalopram, didesmethylcitalopram (weakly active) | 80 |
| Escitalopram | 5 hours | 27-32 hours | Liver (3A4, 2D6, 2C19) | S-desmethylcitalopram, S-didesmethylcitalopram (weakly active) | 56 |
