| Clue | Diagnosis |
| Positive tuberculin skin test or interferon-gamma release assay | Tuberculosis |
| Residence or travel to the southwestern United States, southern California, or Mexico | Coccidioidomycosis |
| Hypothalamic, optic, or pituitary lesions on cranial imaging | Sarcoidosis |
| Uveitis/iritis | Sarcoidosis, Behçet's disease, Vogt-Koyanagi-Harada syndrome |
| Radiculopathy and/or cranial nerve palsies | Lyme disease |
| Prior residence in Mexico, Central or South America, India, sub-Saharan Africa, or the Caribbean | Cysticercosis |
| Exposure to unpasteurized milk or contact with cows, goats, swine, or sheep (including butchering or working in a packing house) | Brucellosis |
| Peripheral 7th nerve paralysis | Sarcoidosis |
| Diabetes insipidus | Sarcoidosis |
| Poliosis (whitening of the eyebrows and eyelashes and vitiligo) | Vogt-Koyanagi-Harada syndrome |
| Recurrent genital or oral ulcerations | Behçet's disease |
| A preexisting immunosuppressive condition or therapy | Cryptococcosis, tuberculosis, toxoplasmosis, endemic mycoses |
| Predominately neutrophilic CSF pleocytosis | Nocardiosis, actinomycosis, aspergillosis, systemic lupus erythematosus, chemical or drug-induced meningitis |
| Eosinophilic CSF pleocytosis | Coccidioidomycosis, lymphoma, Angiostrongylus, cysticercosis, schistosomiasis |
| Hypogammaglobulinemia | Enterovirus |
