| Indication | Clinical presentation | Possible diagnosis | Biopsy technique |
| Diagnosis | Rashes or blisters involving dermis | Drug reaction | Punch |
| Cutaneous lymphoma | |||
| Deep tissue infection | |||
| Erythema multiforme | |||
| Kaposi's sarcoma | |||
| Lupus erythematosus | |||
| Pemphigoid | |||
| Psoriasis | |||
| Vasculitis | |||
| Processes involving the subcutis | Panniculitis (eg, erythema nodosum) | Excision | |
| Diagnosis and treatment | Atypical moles and pigmented lesions | Dysplastic nevi | Excision or punch (for small lesions) |
| Malignant melanoma | |||
| Superficial lesions | Actinic keratoses | Shave (into dermis for suspected malignancy) or excision | |
| Basal cell carcinoma | |||
| Seborrheic keratosis | |||
| Pyogenic granuloma | |||
| Skin tags | |||
| Squamous cell carcinoma | |||
| Warts |
