Your activity: 24 p.v.
< Back
your limit has been reached. plz Donate us to allow your ip full access, Email: sshnevis@outlook.com

Causes of mostly unconjugated hyperbilirubinemia

Causes of mostly unconjugated hyperbilirubinemia
Bilirubin overproduction
Extravascular hemolysis
  • Extravasation of blood into tissues
  • Hypersplenism
Intravascular hemolysis
  • Inherited red blood cell disorders
  • Glucose-6-phosphate dehydrogenase deficiency*
  • Sickle cell disease*
  • Thalassemia
  • Hereditary spherocytosis
  • Hereditary elliptocytosis
  • Infection – Malaria, bacterial sepsis*
  • Autoimmune hemolytic anemia
  • Microangiopathic hemolytic anemia
  • Drug-induced hemolytic anemia (eg, cephalosporins, penicillins, trimethoprim-sulfamethoxazole)
Impaired hepatic bilirubin uptake
Heart failure
Portosystemic shunts
Some patients with Gilbert syndrome
Certain drugs – Rifamycin, probenecid, flavaspadic acid, bunamiodyl
Impaired bilirubin conjugation
Inherited
  • Crigler-Najjar syndrome
  • Gilbert syndrome*
Acquired
  • Neonates – Physiologic hyperbilirubinemia*, breast milk jaundice*
  • Hyperthyroidism (mechanism unclear)
  • Certain drugs – Ethinyl estradiol, gentamicin (above therapeutic range), novobiocin, antiretroviral drugs
  • Liver diseases
  • Chronic persistent hepatitis
  • Advanced cirrhosis
  • Wilson disease

* Common causes.

¶ Refer to UpToDate content on drug-induced hemolytic anemia.
Data from: Mandl KD. Jaundice-Unconjugated hyperbilirubinemia. In: Textbook of Pediatric Emergency Medicine, Fleisher GR, Ludwig S, Henretig FM (Eds), Lippincott Williams and Wilkins, 2006. p.400.
Graphic 66972 Version 8.0