Percent of patients | ||||||
FOLFOX6* | bFOL | CAPOX | ||||
TREE 1 (n = 49) | TREE 2¶ (n = 71) | TREE 1 (n = 50) | TREE 2 (n = 70) | TREE 1Δ (n = 48) | TREE 2Δ (n = 72) | |
Response rate◊ | 41 | 52 | 20 | 39 | 27 | 46 |
Time to tumor progression, months◊ | 8.7 | 9.9 | 6.9 | 8.3 | 5.9 | 10.3 |
Overall survival, months◊ | 19.2 | 26.1 | 17.9 | 20.4 | 17.2 | 24.6 |
Grade 3 to 4 toxicity, percent | ||||||
Vomiting or nausea | 31 | 7 | 24 | 24 | 38 | 21 |
Diarrhea | 31 | 11 | 26 | 26 | 31 | 19 |
Neutropenia | 53 | 49 | 18 | 19 | 15 | 10 |
Hand-foot syndrome | 8 | 0 | 2 | 0 | 19 | 10 |
Sensory neurotoxicity | 18 | 11 | 10 | 9 | 21 | 11 |
Hypertension | 0 | 7 | 0 | 13 | 2 | 15 |
Deep vein thrombosis | 6 | 4 | 2 | 1 | 0 | 3 |