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Cytoplasmic and mitochondrial distribution of heme synthesis enzymatic steps in the erythroblast

Cytoplasmic and mitochondrial distribution of heme synthesis enzymatic steps in the erythroblast
Refer to UpToDate for details of conditions caused by specific enzyme deficiencies.
ALAS2: 5-aminolevulinate synthase; PLP: pyridoxal 5'-phosphate; FECH: ferrochelatase; Tf: transferrin.
Modified from: Bottomley, SS. Iron overload in sideroblastic and other non- thalassemic anemias. In: Hemochromatosis: Genetics, Pathophysiology, Diagnosis and Treatment. Barton, JC, Edwards, CQ (Eds), Cambridge University Press, Cambridge UK 2000. p.422.
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