| Antibiotic | Route | Typical pediatric dose | Comment(s) |
| Preferred agents | |||
| Ciprofloxacin | Oral | 30 mg/kg/day (divided twice daily) for 3 days | Multi-dose therapy is preferred. |
| Azithromycin | Oral | 15 mg/kg initial dose on day 1 10 mg/kg daily on days 2-5 | |
| Alternative agents | |||
| Ceftriaxone | IM/IV | 50-100 mg/kg once daily for 2-5 days | Ceftriaxone is the preferred empiric therapy for severe infections and infections refractory to other therapies. |
| Pivmecillinam | Oral | 80 mg/kg/day (divided 4 times daily) for 5 days | |
