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Major causes of chronic secretory diarrhea*

Major causes of chronic secretory diarrhea*
Factitious diarrhea (laxative abuse)
Rectal villous adenoma
Neuroendocrine tumors
VIPoma
Carcinoid syndrome
Gastrinoma (Zollinger-Ellison syndrome)
Lymphocytic or collagenous colitis
Congenital diarrhea
Bile salt enteropathy
Enterotoxic Escherichia coli
* Secretory diarrhea is defined as diarrhea associated with a stool osmolal gap less than 50 mosmol/kg.
Modified from: Donowitz M, Kokke FT, Saidi R. Evaluation of patients with chronic diarrhea. N Engl J Med 1995; 332:725.
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