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Uptodate Reference Title
Model of the TSH receptor
Model of the TSH receptor
The TSHR first appears on the plasma membrane as an intact holoreceptor. This model shows the 7 transmembrane domains and the large extracellular domain. The extracellular domain consists of the 9 leucine-rich repeats in the ectodomain, which is the major site of TSH binding, and the 50 amino acid cleaved region.
Adapted from: Latif R, Morshed SA, Zaidi M, Davies TF. The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling. Endocrinol Metab Clin North Am. 2009; 38:319.
