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Laboratory findings in the different causes of osteomalacia and osteoporosis

Laboratory findings in the different causes of osteomalacia and osteoporosis
Disorder Serum phosphate Serum calcium Serum alkaline phosphatase Parathyroid hormone 25-hydroxyvitamin D 1,25-dihydroxyvitamin D
Vitamin D deficiency ↓ or N ↓ or N ↓↓ N or ↑ or ↓
Conditions associated with urinary phosphate wasting ↓↓ N N or ↑ N N N
Proximal renal tubular acidosis N N N N N
Hypophosphatasia N N N N N
Osteogenesis imperfecta and axial osteomalacia N N N or ↑ N N N
Osteoporosis N N N N N or ↓ N
N: normal; ↓: reduced; ↓↓: very reduced; ↑: elevated.
Graphic 65400 Version 3.0