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Comparison of sensitivity and specificity for rectal suction biopsy, contrast enema, and anorectal manometry in the diagnosis of Hirschsprung disease in children*

Comparison of sensitivity and specificity for rectal suction biopsy, contrast enema, and anorectal manometry in the diagnosis of Hirschsprung disease in children*
Test Sensitivity Specificity
Rectal suction biopsy 93% 100%
(95% CI, 77-98 percent) (95% CI, 96-100 percent)
Contrast enema 76% 97%
(95% CI, 57-89 percent) (95% CI, 91-99 percent)
Anorectal manometry 83% 93%
(95% CI, 63-93 percent) (95% CI, 85-97 percent)
* Diagnosis was confirmed by full-thickness rectal biopsy and exluded by clinical follow-up for at least 6 months.
Data from: De Lorijn, F, Reitsma, JB, Voskuijl, WP, et al. Diagnosis of Hirschsprung's disease: a prospective, comparative accuracy study of common tests. J Pediatr 2005; 146:787.
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