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Uptodate Reference Title
Bilirubin synthesis
Bilirubin synthesis
Conversion of heme to biliverdin and then bilirubin. Heme ring-opening at the alpha-carbon bridge of heme is catalyzed by heme oxygenase, resulting in the formation of biliverdin. This is followed by reduction of biliverdin to bilirubin in a reaction catalyzed by biliverdin reductase.