| Inhibition of membrane transporters |
| Clarithromycin, fluoroquinolones (eg, levofloxacin), verapamil |
| Decreased hepatic CYP2C metabolism |
| Antiinfectives: Clarithromycin, fluconazole, metronidazole, isoniazid, miconazole (oral), trimethoprim-sulfamethoxazole (and other sulfonamide antibiotics), voriconazole Other: Amiodarone, capecitabine, cimetidine, fluorouracil, fluvastatin, gemfibrozil (and other fibric acid derivatives), losartan, MAO inhibitors¶, mifepristone, nicardipine, omeprazole, ticagrelor, warfarin |
| Intrinsic hypoglycemic activity |
| Alcohol, androgens (anabolic steroids), beta-blockers (variable effects), fluoroquinolones, MAO inhibitors¶, pentamidine, quinine, salicylates*, other antihyperglycemic drugs |
| Decreased renal excretion |
| Allopurinol, probenecid, salicylates* |
| Masks autonomic signs of hypoglycemia |
| Beta-blockers |
