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Definition of bronchopulmonary dysplasia: Diagnostic criteria 2001 NICHD consensus workshop

	Gestational age
	<32 weeks	≥32 weeks
Time point of assessment	36 weeks PMA or discharge to home, whichever comes first	>28 days but <56 days postnatal age or discharge to home, whichever comes first
	Treatment with oxygen >21% for at least 28 days plus
Mild BPD	Breathing room air at 36 weeks PMA or discharge, whichever comes first	Breathing room air by 56 days postnatal age or discharge, whichever comes first
Moderate BPD	Need* for <30% oxygen at 36 weeks PMA or discharge, whichever comes first	Need* for <30% oxygen at 56 days postnatal age or discharge, whichever comes first
Severe BPD	Need* for ≥30% oxygen and/or positive pressure (PPV or nCPAP) at 36 weeks PMA or discharge, whichever comes first	Need* for ≥30% oxygen and/or positive pressure (PPV or nCPAP) at 56 days postnatal age or discharge, whichever comes first

BPD usually develops in neonates being treated with oxygen and PPV for respiratory failure, most commonly, respiratory distress syndrome. Persistence of clinical features of respiratory disease (tachypnea, retractions, rales) are considered common to the broad description of BPD and have not been included in the diagnostic criteria describing the severity of BPD. Infants treated with oxygen >21% and/or positive pressure for nonrespiratory disease (eg, central apnea or diaphragmatic paralysis) do not have BPD unless they also develop parenchymal lung disease and exhibit clinical features of respiratory distress. A day of treatment with oxygen >21% means that the infant received oxygen >21% for more than 12 hours on that day. Treatment with oxygen >21% and/or positive pressure at 36 weeks PMA, or at 56 days postnatal age or discharge, should not reflect an "acute" event but should rather reflect the infant's usual daily therapy for several days preceding and following 36 weeks PMA, 56 days postnatal age, or discharge.

NICHD: National Institute of Child Health and Human Development; PMA: postmenstrual age; BPD: bronchopulmonary dysplasia; PPV: positive pressure ventilation; nCPAP: nasal continuous positive airway pressure.
* A physiologic test confirming that the oxygen requirement at the assessment time point remains to be defined. This assessment may include a pulse oximetry saturation range.

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