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MMR vaccine in adults

MMR vaccine in adults
Vaccine Antibody response Protection against disease Dose Most common side effects Contraindications
MMR

Single dose: 0.5 mL SC

Second dose if required: 0.5 mL SC at least 28 days later

Most rare after revaccination

Fever, rash

Lymphadenopathy

Febrile seizures

Allergic reactions

Thrombocytopenia

Arthritis, arthralgias

Pregnancy current or planned within 28 days

Immunocompromised (refer to related UpToDate topics)

Anaphylaxis after eating eggs or receiving neomycin

Recent administration of immune globulin (delay vaccine administration for at least six months after intramuscular administration or eight months after intravenous administration)
Measles 99 percent (after 2 doses) 99 percent - Lifelong
Mumps 97 percent (after 1 dose) 75 to 95 percent >30 years
Rubella 95 percent (after 1 dose) 90 percent >15 years ? lifelong
MMR: measles, mumps, and rubella; SC: subcutaneously.
Adapted from: Watson JC, Pearson JA, Markowitz LE, et al. Pediatrics 1996; 97:613; Weibel RE, Sokes J Jr, Buynak EB, et al. N Engl J Med 1967; 276:245; Balfour HH, Groth KE, Edelman CK. Am J Dis Child 1990; 134:350; O'Shea S, Best JM, Banatvala JE. J Infect Dis 1983; 148:639; Watson JC, Hadler SC, Dykewicz CA, et al. MMWR Recomm Rep 1998; 47:1.
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