| Drug | Dose | Initiation relative to PCI | Duration of therapy |
| Abciximab | 0.25 mg/kg IV bolus, then 0.125 mcg/kg/min IV (max 10 mcg/min). | 10 to 60 min prior to PCI | 12 hours |
| Renal adjustment: none. | |||
| Eptifibatide | 180 mcg/kg IV bolus x2, 10 min apart (max 22.6 mg each bolus). Start infusion of 2 mcg/kg/min (max 15 mg/hr) after first bolus. | Immediately prior to PCI | 12 to 18 hours |
| Renal adjustment of continuous infusion: CrCl* <50 mL/min: 1 mcg/kg/min (max 7.5 mg/hr). | |||
| Hemodialysis dependent: contraindicated. | |||
| Tirofiban | Not generally used in elective PCI. | ||
| Unfractionated heparin | 60 to 100 units/kg IV bolus, titrate to ACT 250 to 300 sec (50 to 70 units/kg IV if GP IIb/IIIa used, titrate to ACT 200 to 250 sec). | Immediately prior to PCI | Heparin is discontinued at the end of the procedure |
| Renal adjustment: none. | |||
| Enoxaparin | Not generally started for elective PCI. For the occasional patient already on drug, it can be continued at prior dose with an additional 0.3 mg/kg IV if 8 to 12 hours since last dose. | May continue for prior indication | |
| Renal adjustment: avoid use if CrCl* <30 mL/min or dialysis dependent. | |||
| Bivalirudin | 0.75 mg/kg IV bolus, then 1.75 mg/kg/hr IV. | Immediately prior to PCI | Bivalirudin is discontinued at the end of the procedure |
| Renal adjustment of continuous infusion: CrCl* 10 to 29 mL/min: 1 mg/kg/hr. | |||
| Hemodialysis dependent: 0.25 mg/kg/hr. |
