American Heart Association (AHA)¶ | European Society of Cardiology (ESC) | British Society for Antimicrobial Therapy (BSAC) | |
Adult dose | Pediatric dose | Adult dose | Adult dose |
Strains with intrinsic penicillin resistanceΔ | |||
Vancomycin◊ 30 mg/kg per 24 hours IV in two divided doses for six weeks plus Gentamicin§ 3 mg/kg per 24 hours IV or IM in three divided doses for six weeks | Vancomycin◊ 40 mg/kg per 24 hours IV (maximum dose: 2 g per 24 hours unless levels are inappropriately low) in two or three divided doses for six weeks plus Gentamicin§ 3 to 6 mg/kg per 24 hours IV in three divided doses for six weeks | Vancomycin◊ 30 mg/kg per 24 hours IV in two divided doses for six weeks plus Gentamicin§ 3 mg/kg per 24 hours IV or IM in one dose for six weeks | Vancomycin◊ 1 g IV every 12 hours for four to six weeks† or Teicoplanin¥ 10 mg/kg IV once daily for four to six weeks† plus Gentamicin§ 1 mg/kg IV every 8 to 12 hours for four to six weeks† |
Beta-lactamase-producing strains | |||
Ampicillin-sulbactam‡ 3 g every 6 hours IV for six weeks or Vancomycin◊ 30 mg/kg per 24 hours IV in two divided doses for six weeks plus Gentamicin§ 3 mg/kg per 24 hours IV or IM in three divided doses for six weeks | See above | Ampicillin-sulbactam‡ 12 g per 24 hours (or 300 mg/kg per 24 hours) IV in four equally divided doses for four to six weeks† or Amoxicillin-clavulanate‡ 200 mg/kg (amoxicillin component) per 24 hours IV in six equally divided doses for four to six weeks† or Vancomycin◊ 30 mg/kg per 24 hours IV in two divided doses for six weeks plus Gentamicin§ 3 mg/kg per 24 hours IV or IM in one dose for four to six weeks† |