| Clinician request |
| Third loss, does not need to be consecutive |
| Nonimmune hydrops fetalis |
| Severe growth restriction (<3rd percentile by best estimate of gestational age) |
| One anomaly in first-trimester loss |
| Two anomalies for all other losses |
| Single "specific" anomaly known to be associated with a specific karyotypic or microarray anomaly (eg, complete common atrioventricular canal in Trisomy 21) |
| Known maternal or paternal balanced translocation |
| Verification of abnormal amniotic fluid-based karyotype and/or microarray |
