| Suppression of HBV replication |
| Clearance of HBV DNA from serum |
| Clearance of HBeAg with or without the development anti-HBe antibodies |
| Improvement in liver disease |
| Normalization in ALT level |
| Decrease in necroinflammatory activity on liver biopsies |
| Eradication of HBV (which is seldom achieved) |
| Clearance of HBsAg with or without the development of anti-HBs antibodies |
| Clearance of HBV DNA from serum (by PCR); rare in patients who remain HBsAg positive |
| Disappearance of HBV DNA from liver |
| Prevention of cirrhosis and hepatocellular carcinoma and improvement in survival |
| Scanty data |
