| Genotype C | Genotype B | |
| Prevalence of HBeAg | High | Low |
| Spontaneous HBeAg seroconversion | Late | Early |
| Histological activity | High | Low |
| Rate of progression to cirrhosis | High | Low |
| Risk of HCC | High | Low (Japan, China) |
| Variable (Taiwan) | ||
| Frequency of PC variant (G1896A) | Low | High |
| Frequency of CP variant (A1762T, G1764A) | High | Low |
| Response to IFN | Low | High |
| (Similar in 1 study on PEG-IFN) | ||
| Response to nucleotide(side) analogues | ||
| On treatment | Similar | Similar |
