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Black thyroid syndrome

Black thyroid syndrome
(A) Gross thyroid specimen with diffuse black discoloration from tetracycline use.
(B) LM image showing black pigment deposition in the thyroid colloid.
(C) Higher magnification of LM demonstrating black material within the colloid and the surrounding follicular cells.
(D) Electron microscopy image showing black pigment within cellular lysosomes.
LM: light microscopy.
Reproduced with permission from: Yusim A, Ghofrani M, Ocal IT, Roman S. Black thyroid syndrome. Thyroid 2006; 16:811. Copyright ©2006 Mary Ann Liebert, Inc.
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