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Vasoactive medication receptor activity and clinical effects

Drug	Receptor activity				Predominant clinical effects
Drug	Alpha-1	Beta-1	Beta-2	Dopaminergic	Predominant clinical effects
Phenylephrine	+++	0	0	0	SVR ↑ ↑, CO ↔/↑
Norepinephrine	+++	++	0	0	SVR ↑ ↑, CO ↔/↑
Epinephrine	+++	+++	++	0	CO ↑ ↑, SVR ↓ (low dose) SVR/↑ (higher dose)
Dopamine (mcg/kg/min)*
0.5 to 2.	0	+	0	++	CO
5. to 10.	+	++	0	++	CO ↑, SVR ↑
10. to 20.	++	++	0	++	SVR ↑ ↑
Dobutamine	0/+	+++	++	0	CO ↑, SVR ↓
Isoproterenol	0	+++	+++	0	CO ↑, SVR ↓

Vasoactive_receptor_activit.htm

+++: Very strong effect; ++: Moderate effect; +: Weak effect; 0: No effect; SVR: systemic vascular resistance; CO: cardiac output.
* Doses between 2. and 5. mcg/kg/min have variable effects.

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