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Osteoporosis screening recommendations

Osteoporosis screening recommendations
National Osteoporosis Foundation (NOF) The NOF recommends measurement of BMD (DXA of the hip and spine) in[1]:
  • Women age 65 years and older and men age 70 years and older, regardless of clinical risk factors.
  • Younger postmenopausal women, women in the menopausal transition, and men age 50 to 69 years with clinical risk factors for fracture.
  • Adults who have a fracture after age 50 years.
  • Adults with a condition (eg, rheumatoid arthritis) or taking a medication (eg, glucocorticoids in a daily dose ≥5 mg prednisone or equivalent for ≥3 months) associated with low bone mass or bone loss.
International Society for Clinical Densitometry (ISCD) The ISCD recommends measurement of BMD (DXA of the hip and spine) in[2]:
  • All women age 65 years and older and men age 70 years and older regardless of risk factors.
  • Postmenopausal women and men age 50 to 70 years when risk factors are present.
  • Adults with a fragility fracture.
  • Adults with a condition or taking a medication associated with low bone mass or bone loss.
  • Anyone being considered for pharmacologic therapy for osteoporosis.
  • Anyone being treated for osteoporosis to monitor response to therapy.
  • Anyone not receiving therapy when evidence of bone loss would lead to treatment.
  • Women in the menopausal transition if there is a specific risk factor associated with increased fracture, such as low body weight, prior low-trauma fracture, or high-risk medication.
  • Postmenopausal women discontinuing estrogen should be considered for bone density testing.
  • The 33% forearm (one-third radius) site is recommended in the following cases:
    • If hip and/or spine cannot be measured or interpreted
    • Hyperparathyroidism
    • Severe obesity (over the weight limit of DXA table)
Association of Clinical Endocrinologists (AACE) AACE recommends measurement of BMD (DXA) in[3]:
  • All women age 65 years and older.
  • Any adult with a history of fracture not caused by severe trauma.
  • Younger postmenopausal women with clinical risk factors for fracture.
  • The lumbar spine (PA) and proximal femur are recommended sites of measurement.
United States Preventive Services Task Force (USPSTF) USPSTF recommends measurements of BMD in[4]:
  • All women age 65 years and older.
  • In addition, they recommend screening in younger women whose fracture risk is equal to or greater than that of a 65-year-old White woman who has no additional risk factors.
  • The best site to screen is not mentioned, although the report agrees that DXA of the hip is the best predictor of hip fracture.
American Academy of Family Physicians (AAFP) The AAFP recommends measurement of BMD in[5]:
  • Women age 65 years and older.
  • Women age 60 years and older at increased risk for osteoporotic fracture.
National Institutes of Health (NIH) The NIH recommends[6]:
  • BMD measurements for individuals at high risk for osteoporosis. They do not recommend universal screening.
North American Menopause Society (NAMS) The NAMS recommends measurement of BMD (DXA) in[7]:
  • Women age 65 and older.
  • Postmenopausal women with medical causes of bone loss or clinical risk factors for fracture, regardless of age.
  • Postmenopausal women with a fragility fracture.
American College of Preventative Medicine (ACPM) The ACPM recommends measurement of BMD (DXA) in[8]:
  • Women age 65 and older.
  • Men age 70 and older.
  • Younger postmenopausal women and men aged 50 to 69 years with additional clinical risk factors for fracture.
American College of Obstetrics and Gynecology (ACOG) The ACOG recommends measurement of BMD (DXA) in[9]:
  • Women age 65 and older.
  • Women under age 65 with additional clinical risk factors for fracture.
  • Alternatively, women under age 65 with FRAX 10-year risk of major osteoporotic fracture of 9.3% or higher.
UK National Osteoporosis Guideline Group (NOGG) The NOGG does not recommend population screening. They are in favor of performing BMD measurements using a case-finding strategy based upon age-specific fracture probability thresholds[10].
Canadian Osteoporosis Society The Canadian Osteoporosis Society recommends BMD measurement in[11]:
  • Postmenopausal women age 65 years and older.
  • Men age 65 years and older.
  • Younger men and women with additional clinical risk factors for fracture.
BMD: bone mineral density; DXA: dual-energy x-ray absorptiometry; FRAX: Fracture Risk Assessment Tool.
References:
  1. National Osteoporosis Foundation. 2013 Clinician's Guide to Prevention and Treatment of Osteoporosis. http://nof/public/content/resource/913/files/580.pdf (Accessed on November 14, 2013).
  2. International Society for Clinical Densitometry. 2013 ISCD Official Positions - Adult. www.iscd.org/official-positions/2013-iscd-official-positions-adult/ (Accessed on November 14, 2013).
  3. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Postmenopausal Osteoporosis. www.aace.com/pub/pdf/guidelines/OsteoGuidelines2010.pdf (Accessed on January 10, 2011).
  4. US Preventive Services Task Force, Curry SJ, Krist AH, et al. Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement. JAMA 2018; 319:2521.
  5. American Academy of Family Physicians. Recommendations for clinical preventative services. www.aafp.org/exam.xml (Accessed on January 10, 2011).
  6. www.consensus.nih.gov (Accessed on January 10, 2011).
  7. Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society. Menopause 2021; 28:973.
  8. Lim LS, Hoeksema LJ, Sherin K. Screening for osteoporosis in the adult U.S. population: ACPM position statement on preventive practice. Am J Prev Med 2009; 36:366.
  9. Committee on Practice Bulletins-Gynecology, The American College of Obstetricians and Gynecologists. ACOG Practice Bulletin N. 129. Osteoporosis. Obstet Gynecol 2012; 120:718.
  10. National Osteoporosis Guideline Group (NOGG). www.shef.ac.uk/NOGG/index.html (Accessed on June 29, 2011).
  11. Papaioannou A, Morin S, Cheung AM, et al. 2010 Clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: Summary. CMAJ 2010; 182:1864.
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