Criteria |
- Evidence of involvement of 3 or more organs, systems, and/or tissues
|
- Development of manifestations simultaneously or in less than a week
|
- Confirmation by histopathology of small vessel occlusion in at least 1 organ or tissue
|
- Laboratory confirmation of the presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin antibodies, and/or anti-beta2-glycoprotein I antibodies)
|
Classification |
Definite catastrophic APS |
Requires all 4 criteria |
Probable catastrophic APS |
All 4 criteria, except for only two organs, systems, and/or sites of tissue involvement or |
All 4 criteria, except for the laboratory confirmation at least 6 weeks apart due to the early death of a patient never tested for aPL before the catastrophic APS or |
Criteria 1, 2, and 4 above or |
1, 3, and 4 and the development of a third event in more than a week but less than a month, despite anticoagulation |