Changing presentation of primary hyperparathyroidism
Changing presentation of primary hyperparathyroidism
Different patterns of presentation of primary hyperparathyroidism in three different time periods. The latest survey shows that 80 percent of patients are asymptomatic and discovered incidentally on routine blood screening; bone disease (osteitis fibrosa cystica), on the other hand, has virtually disappeared as a presenting symptom. Bone disease was assessed by radiographs and bone densitometry; patients with skeletal involvement by bone density measurement were not included.
Data from:
Cope O. The study of hyperparathyroidism at the Massachusetts General Hospital. N Engl J Med 1966; 274:1174.
Heath H III, Hodgson SF, Kennedy MA. Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community. N Engl J Med 1980; 302:189.
Silverberg SJ, Shane E, Jacobs TP, et al. Nephrolithiasis and bone involvement in primary hyperparathyroidism. Am J Med 1990; 89:327.
