| Mechanism | Symptoms | Signs |
| Slowing of metabolic processes | Fatigue and weakness Cold intolerance Dyspnea on exertion Weight gain Cognitive dysfunction Intellectual disability (infantile onset) Constipation Growth failure | Slow movement and slow speech Delayed relaxation of tendon reflexes Bradycardia Carotenemia |
| Accumulation of matrix substances | Dry skin Hoarseness Edema | Coarse skin Puffy facies and loss of eyebrows Periorbital edema Enlargement of the tongue |
| Other | Decreased hearing Myalgia and paresthesia Depression Menorrhagia Arthralgia Pubertal delay | Diastolic hypertension Pleural and pericardial effusions Ascites Galactorrhea |
