This 37-year-old woman underwent in vitro fertilization and was treated with 800 mg of progesterone each day for seven days. She developed cholestasis, jaundice, and small pruritic papules on elbows, hands, and knees. She had a family history of diabetes but was free of disease. Blood tests were characteristic of type IV hyperlipoproteinemia with hypertriglyceridemia, hypercholesterolemia, decreased LDLs, decreased HDLs, and elevated liver enzymes.
