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Causes of severe fetal anemia potentially leading to hydrops fetalis

Causes of severe fetal anemia potentially leading to hydrops fetalis
Alpha-thalassemia
Fetomaternal hemorrhage
In utero fetal hemorrhage
Pure red cell aplasia
Pyruvate kinase deficiency
Glucose phosphate isomerase deficiency
Glucose-6-phosphate dehydrogenase deficiency
Spectrin protein abnormality or deficiency
Transient myeloproliferative disorder
Leukemoid reaction in response to congenital infection
Congenital leukemia
Kasabach-Merritt syndrome (microangiopathic hemolytic anemia, DIC)
Blackfan Diamond anemia
Infections, such as cytomegalovirus, toxoplasmosis, syphilis, parvovirus
Lysosomal storage diseases
Fanconi anemia
Aneuploidy
Twin-twin transfusion syndrome, twin anemia-polycythemia sequence
Immune mediated fetal anemia is related to alloimmunization to red blood cell antigens, Rhesus or non-Rhesus.
DIC: disseminated intravascular coagulation.
Modified from: Arcasoy M, Gallagher P. Hematologic Disorders and Nonimmune Hydrops Fetalis. Semin Perinatol 1995; 19:502.
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