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Drugs implicated in the development of subacute cutaneous lupus

Drugs implicated in the development of subacute cutaneous lupus
ACE inhibitors (captopril, cilazapril)
Antiarrhythmics (procainamide)
Antiseizure medications (phenytoin, lamotrigine)
Antifungals (griseofulvin, terbinafine)
Antihistamines (cinnarizine/thiethylperazine)
Antineoplastics (docetaxel, paclitaxel, anastrozole, gemcitabine, doxorubicin, tamoxifen, leuprorelin)
Beta blockers (acebutolol, oxprenolol)
Calcium channel blockers (diltiazem, nifedipine, nitrendipine, verapamil)
Diuretics (hydrochlorothiazide, spironolactone)
Immune modulators (leflunomide, interferon-alpha, interferon-beta)
Lipid-lowering agents (pravastatin, simvastatin)
NSAIDs (naproxen, piroxicam)
Proton pump inhibitors (omeprazole, lansoprazole, pantoprazole)
Sulfonylureas (glyburide)
TNF-alpha inhibitors (etanercept, infliximab, adalimumab, golimumab)
Others (D-penicillamine, bupropion, ticlopidine, ranitidine*)
ACE: angiotensin-converting enzyme; NSAIDs: nonsteroidal anti-inflammatory drugs; TNF: tumor necrosis factor.
* Ranitidine has been withdrawn from the United States market.
Data from:
  1. Sontheimer RD, Henderson CL, Grau RH. Drug-induced subacute cutaneous lupus erythematosus: a paradigm for bedside-to-bench patient-oriented translational clinical investigation. Arch Dermatol Res 2009; 301:65.
  2. Vedove CD, Del Giglio M, Schena D, Girolomoni G. Drug-induced lupus erythematosus. Arch Dermatol Res 2009; 301:99.
  3. Sheth N, Greenblatt D, Patel S, Acland K. Adalimumab-induced cutaneous lupus. Clin Exp Dermatol 2007; 32:593.
  4. Adachi A, Horikawa T. Paclitaxel-induced cutaneous lupus erythematosus in patients with serum anti-SSA/Ro antibody. J Dermatol 2007; 34:473.
  5. Trancart M, Cavailhes A, Balme B, Skowron F. Anastrozole-induced subacute cutaneous lupus erythematosus. Br J Dermatol 2008; 158:628.
  6. Wiechert A, Tuting T, Bieber T, et al. Subacute cutaneous lupus erythematosus in a leuprorelin-treated patient with prostate carcinoma. Br J Dermatol 2008; 159:231.
  7. Funke AA, Kulp-Shorten CL, Callen JP. Subacute cutaneous lupus erythematosus exacerbated or induced by chemotherapy. Arch Dermatol 2010; 146:1113.
  8. Wiznia LE, Subtil A, Choi JN. Subacute cutaneous lupus erythematosus induced by chemotherapy: gemcitabine as a causative agent. JAMA Dermatol 2013; 149:1071.
  9. Grönhagen CM, Fored CM, Linder M, et al. Subacute cutaneous lupus erythematosus and its association with drugs: a population-based matched case-control study of 234 patients in Sweden. Br J Dermatol 2012; 167:296.
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