Heart failure with amlodipine versus chlorthalidone in ALLHAT

Increased relative risk of heart failure with amlodipine. Graph, with natural logarithmic scale, showing the relative risk of heart failure in all studied patients (total) and prespecified subgroups given either amlodipine or chlorthalidone in the ALLHAT study. Compared with chlorthalidone, amlodipine increased the risk of heart failure in total and in all specific subgroups.