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Single-agent cytotoxic chemotherapy for desmoid tumors

Single-agent cytotoxic chemotherapy for desmoid tumors
Agent Number of patients studied Dose Response Duration of response Author; year
Doxorubicin 1

70 mg/m2 every three weeks

Dose reduced after two cycles to 50 mg/m2

Cumulative dose of 450 mg/m2

PR >4 years after cessation of chemotherapy Seiter K; 1993
Doxorubicin 6 NR 3 PR NR de Camargo VP; 2010
Epirubicin 1 30 mg/m2 every three weeks PR >1 year Giaccone G; 1989
Pegylated liposomal doxorubicin

1 adult

3 children

20 to 50 mg/m2

Cumulative dose of 160 to 430 mg/m2

3 PR

1 SD

9 to 40 months of follow-up, no progression seen Wehl G; 2004
Pegylated liposomal doxorubicin 22 NR 8 PR NR de Camargo VP; 2010
Pegylated liposomal doxorubicin 14 40 to 50 mg/m2 every four weeks, up to six cycles

4 PR

10 SD

9 to 45 months Constantinidou A; 2010
PR: partial response, ≥30% reduction in maximal dimension; NR: not reported; SD: stable disease.
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