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Treatment of myxedema coma

Treatment of myxedema coma
Draw serum for T4, TSH, and cortisol.
Administer levothyroxine 200 to 400 mcg intravenously, followed by daily doses of 50 to 100 mcg, and triiodothyronine 5 to 20 mcg intravenously, followed by 2.5 to 10 mcg every eight hours.*
Change to an appropriate oral dose of levothyroxine when the patient can tolerate oral medications. (Oral dose is approximately the intravenous dose divided by 0.75).
 Hydrocortisone 100 mg intravenously every eight hours until exclusion of possible adrenal insufficiency.
Supportive measures:
Mechanical ventilation
Fluids and vasopressor drugs to correct hypotension
Passive rewarming
Intravenous dextrose
Consider empirical antibiotic treatment
Monitor for arrhythmias and treat when indicated
T4: thyroxine; TSH: thyroid-stimulating hormone.
* The lower end of the dose ranges is preferred in lower weight and older patients and those at risk for cardiac complications. Refer to accompany UpToDate topic on myxedema coma.
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