Acquired |
Tumors |
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- Germinomas, meningiomas, gliomas, astrocytomas
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- Metastatic tumors (breast, lung, prostate)
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"Functional" gonadotropin deficiency |
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- Hypothyroidism, hyperprolactinemia, diabetes mellitus, Cushing's disease
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- Anorexia nervosa, bulimia
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- Drugs - marijuana, opioids, anabolic steroids, glucocorticoids
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Infiltrative diseases |
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Head trauma |
Pituitary apoplexy |
Congenital |
Isolated GnRH deficiency |
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- Associated with adrenal hypoplasia congenita
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GnRH deficiency associated with intellectual disability/obesity |
- Laurence-Moon-Biedl syndrome
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Idiopathic forms of multiple anterior pituitary hormone deficiencies |
Congenital malformations often associated with craniofacial anomalies |