| Diagnostic category | Site of lesion | ||||
| Upper motor neuron | Anterior horn cell | Peripheral nerve | NM junction | Muscle | |
| Genetic | Leukodystrophies | Spinal muscular atrophy | Peroneal muscular atrophy | Myasthenia gravis | Muscular dystrophies |
| Inflammatory | Vasculitis | Amyotrophic lateral sclerosis | Guillain- Barre | Myasthenia gravis | Polymyositis |
| Infectious | Brain abscess | Poliomyelitis | Leprosy | Botulism | HIV |
| Neoplastic | Brain tumor | Paraneoplastic syndrome | Myeloma/ amyloid | Eaton-Lambert syndrome | Malignancy- associated myositis |
| Toxic/drug | Radiation | Lead | Lead | Organophosphate poisoning | Steroid |
| Metabolic/ endocrine | Vitamin B12 deficiency | Diabetes | --- |
Hypothyroid Hypoglycemia |
|
