| Decreased platelet production |
| Infection (Epstein-Barr virus, cytomegalovirus, parvovirus, varicella, rickettsia, bacterial sepsis) |
| Nutritional deficiencies (folate, B12, iron) |
| Acquired bone marrow failure |
| Aplastic anemia |
| Myelodysplastic syndromes |
| Medications (eg, chemotherapy) |
| Radiation |
| Infiltrative bone marrow diseases |
| Leukemias |
| Lymphomas |
| Metastatic cancers |
| Infectious granulomas |
| Storage diseases |
| Genetic causes of impaired thrombopoiesis* |
| Wiskott-Aldrich syndrome/X-linked thrombocytopenia |
| Inherited bone marrow failure syndromes |
| Fanconi anemia |
| Dyskeratosis congenita |
| Shwachman-Diamond syndrome |
| Congenital amegakaryocytic thrombocytopenia |
| Thrombocytopenia with absent radii syndrome |
| Amegakaryocytic thrombocytopenia with radioulnar synostosis |
| Familial platelet disorder with predisposition to hematologic malignancy |
| Bernard-Soulier syndrome |
| MYH9-related disorders |
| Paris-Trousseau syndrome |
| X-linked thrombocytopenia with dyserythropoiesis |
