A sporadic, progressive, adult (>30 years of age)-onset disease characterized by: |
Autonomic failure involving urinary incontinence (inability to control the release of urine from the bladder, with erectile dysfunction in males) or an orthostatic decrease of blood pressure within 3 min of standing by at least 30 mmHg systolic or 15 mmHg diastolic and |
Poorly levodopa-responsive parkinsonism (bradykinesia with rigidity, tremor, or postural instability) or |
A cerebellar syndrome (gait ataxia with cerebellar dysarthria, limb ataxia, or cerebellar oculomotor dysfunction) |