Therapeutic peak plasma level, h | Half-Life, h, therapeutic | Protein binding, percent | Vol. of distribuion, L/kg | Route of metabloism | Active metabolite | |
Traditional agents | 2-5 | 8-36 | 90-95 | 7-62 | CYP2D6 CYP1A2 CYP3A4 | Variable |
Clozapine | 1-4 | 7-13 | 92-95 | 2-5 | CYP1A2 CYP3A4 | Norclozapine |
Olanzapine | 5-6 | 20-30 | 93 | 10-20 | CYP1A2 CYP2D6 | NO |
Quetiapine | 1-2 | 4-10 | 83 | 10 | CYP3A4 | 7-hydroxyquetiapine |
Risperadone | 1-2 | 3-24 | 90 | 1-1.5 | CYP2D6 | 9-hydroxyrisperidone |
Ziprasidone | 4-5 | 4-10 | >99 | 2 | CYP3A4 | NO |
Aripiprazole | 3-5 | 75-146 | >99 | 4.9 | CYP2D6 CYP3A4 | Dehydroaripiprazole |