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Physiological characteristics and clinical effects of commonly used intravenous solutions

Physiological characteristics and clinical effects of commonly used intravenous solutions
  Available solutions
Albumin solutions Starches
4, 5 percent 20, 25 percent 3, 6, 10 percent Hetastarch 10 percent Pentastarch
Molecular weight, average (kD) 69 69 450 280
Osmolality, mOsm/L 290 310 300-310 326
COP, mm Hg 20-30 70-100 23-50 23-50
Maximum volume expansion,* percent 70-100 300-500
100-200 100-200
Duration of volume expansion, h 12-24 12-24 8-36 12-24
Plasmatic half-life, h 16-24 16-24 50 2-12
Potential for adverse reactions + + ++ ++
Possible side effects Allergic reactions Allergic reactions Renal dysfunction Renal dysfunction
Transmitted infection Transmitted infection Coagulopathy Coagulopathy
Pruritus Pruritus
Anaphylactoid reactions Anaphylactoid reactions

COP: colloid osmotic pressure.
* Expressed as a percentage of administered volume.
¶ Starches are rarely used due to increased mortality and renal dysfunction associated with their use.

Am J Respir Crit Care Med Vol 170. pp 1247-1259, 2004.
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