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Hypothesized model of frailty and adverse health outcomes

CRP: C-reactive protein; IL: interleukin; IGF: insulin-like growth factor; DHEA-S: dehydroepiandrosterone sulfate.

Reproduced with permission from: Walston J, Hadley EC, Ferrucci L, et al. Research Agenda for Frailty in Older Adults: Towards a Better Understanding of Physiology and Etiology. J Am Geriatr Soc 2006; 54:991. Copyright © 2006 Wiley-Blackwell.

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