| Pathologic substance | Diseases |
| Immunoglobulins | Hyperviscosity syndrome |
| Waldenström macroglobulinemia | |
| Multiple myeloma | |
| Autoantibodies | Myasthenia gravis |
| Anti-GBM antibody disease | |
| Systemic lupus erythematosus | |
| Systemic vasculitis | |
| Factor VIII inhibitors | |
| Thrombotic thrombocytopenic purpura | |
| Lipoproteins | Hypercholesterolemia |
| Leukocytes | Hyperleukemic leukostasis |
| Platelets | Severe thrombocytosis |
| Abnormal red cells | Sickle cell disease (pain crisis, acute chest syndrome, stroke) |
| Circulating immune complexes | Immune complex glomerulonephritis |
| Systemic lupus erythematosus | |
| Systemic vasculitis | |
| Protein-bound substances and toxins | Thyroid storm |
| Amanita phalloides toxins | |
| Hyperparasitemia | Malaria, babesiosis |
