- Thorough drug exposure history
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- Review of a peripheral blood smear and, in some cases, bone marrow examination
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- Analysis for iron, total iron binding capacity, transferrin saturation, ferritin, folate, vitamin B12, or hemoglobinopathy screening (where indicated)
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- Assessment of reticulocyte count, occult blood loss, and renal insufficiency
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- Baseline erythropoietin level
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- Testing of serum thyroid-stimulating hormone level (where indicated)
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- Investigations may also include direct antiglobulin testing (eg, Coombs test) for patients with chronic lymphocytic leukemia, non-Hodgkin lymphoma, or a history of autoimmune disease
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