| Abnormality | Indicated evaluations |
| Weakness, fatigue, malaise | Evaluation for liver, endocrinologic, and cardiac disorders and for anemia |
| Elevated hepatic enzyme concentrations | Evaluation for hepatitis B, hepatitis C, and other liver diseases (such as drug-related hepatopathy, alpha-1-antitrypsin deficiency, or metastatic cancer); liver biopsy |
| Hepatomegaly or hepatic pain | Evaluation for hepatitis B, hepatitis C, and other liver diseases; liver biopsy; measurement of alpha-fetoprotein concentration; hepatic imaging procedures; liver MRI* |
| Arthralgias or arthropathy | Radiography of affected joints; evaluation for other arthropathies |
| Thyroid dysfunction | Measurement of thyroid-stimulating hormone, thyroxine, and antithyroid antibody concentration if hypothyroid |
| Impotence, premature amenorrhea | Measurement of luteinizing hormone, follicle-stimulating hormone, and sex hormone concentrations; CT of anterior pituitary to evaluate for possible pituitary tumor |
| Cardiac symptoms | Electrocardiography; echocardiographic assessment of ventricular ejection fraction and exercise tolerance; cardiac MRI* |
| Hyperglycemia or diabetes mellitus | Fasting serum glucose and glycosylated hemoglobin levels |
