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Uptodate Reference Title
Pharmacokinetic properties of digoxin
Pharmacokinetic properties of digoxin
Digoxin
Bioavailability (percent)
70
Plasma binding (percent)
25
VD (L/kg)
5.6 L/kg
Half life (hours)*
50
Desired therapeutic concentrations
0.5 to 0.8 ng/mL
* Assumes normal renal function.
Data from:
Lapostolle F, Baud FJ, Borron SW, Mégarbane B. Digitalis glycosides. In: Critical Care Toxicology: Diagnosis and Management of the Critically Poisoned Patient, Brent J, Wallace KL, Burkhart K, et al (Eds), Elsevier Mosby, Philadelphia 2004. p.393.
Holford NHG. Pharmacokinetics and pharmacodynamics: Rational dosing and the time course of drug action. In: Basic and Clinical Pharmacology, 8th ed, Katzung BG (Ed), McGraw Hill, New York 2001. p.35.
