Agent | Regimen | Maximum daily dose |
Intravenous therapy | ||
Ampicillin* | Penicillin susceptible (MIC ≤2 mcg/mL): 150 to 200 mg/kg per day divided in 4 doses | 6 g/day |
Penicillin resistant or intermediate (MIC >2 mcg/mL): 300 to 400 mg/kg per day divided in 4 doses | 12 g/day | |
Cefotaxime¶ | 150 mg/kg per day divided in 3 doses | 6 g/day |
Ceftaroline | 2 through 23 months: 24 mg/kg per day divided in 3 doses | 1.2 g/day |
2 through 17 years:
| ||
≥18 years: 1.2 g per day divided in 2 doses | ||
Ceftriaxone¶ | Penicillin susceptible (MIC ≤2 mcg/mL): 50 to 100 mg/kg per day divided in 1 or 2 doses | 2 g/day |
Penicillin resistant (MIC ≥4 mcg/mL): 100 mg/kg per day divided in 1 or 2 doses | 4 g/day | |
ClindamycinΔ (if susceptible) | 40 mg/kg per day divided in 3 or 4 doses | 2.7 g/day |
Penicillin G* | 200,000 to 250,000 units/kg per day divided in 4 or 6 doses | 24 million units/day |
LevofloxacinΔ (if susceptible) | 6 months to 5 years: 16 to 20 mg/kg per day divided in 2 doses | 750 mg/day |
5 to 16 years: 8 to 10 mg/kg once daily | ||
Linezolid | <12 years: 30 mg/kg per day divided in 3 doses | 1.8 g/day |
≥12 years: 20 mg/kg per day divided in 2 doses | 1.2 g/day | |
VancomycinΔ | 40 to 60 mg/kg per day divided in 3 or 4 doses◊ | 4 g/day◊ |
Oral therapy (for mild infection or completion of a course of therapy initiated intravenously) | ||
Amoxicillin* | 90 mg/kg per day divided in 2 doses | 4 g/day |
45 mg/kg per day divided in 3 doses | 4 g/day | |
Cefpodoxime | 10 mg/kg per day divided in 2 doses | 400 mg/day |
Cefprozil | 15 to 30 mg/kg per day divided in 2 doses | 1 g/day |
Cefuroxime | 20 to 30 mg/kg per day divided in 2 doses | 1 g/day |
ClindamycinΔ (if susceptible) | 30 to 40 mg/kg per day divided in 3 doses | 1.8 g/day |
Levofloxacin¶ (if susceptible) | 6 months to 5 years: 16 to 20 mg/kg per day divided in 2 doses | 750 mg/day |
5 to 16 years: 8 to 10 mg/kg once daily | ||
Linezolid¶ | <12 years: 30 mg/kg per day divided in 3 doses | 1.8 g/day |
≥12 years: 20 mg/kg per day divided in 2 doses | 1.2 g/day |