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Morphologic features associated with malignancy on needle biopsy of the prostate

Morphologic features associated with malignancy on needle biopsy of the prostate
Morphologic feature Malignant lesions, percent (n = 100) Benign lesions, percent (n = 150)
Prominent nucleoli 94 25
Marginated nucleoli 88 7
Multiple nucleoli 64 0
Blue-tinged mucinous secretions 52 0
Intraluminal crystalloids 41 1
Intraluminal amorphous eosinophilic material 87 2
Collagenous micronodules 2 0
Glomerulations 15 0
Perineural invasion 22 0
Retraction clefting 39 7
Invasion of fat 0.7 0
Morphology_prost_CA_needle.htm
Modified from Varma M, Lee MW, Tamboli P, et al. Morphologic criteria for the diagnosis of prostatic adenocarcinoma in needle biopsy specimens. A study of 250 consecutive cases in a routine surgical pathology practice. Arch Pathol Lab Med 2002; 126:554.
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