| Inherited thrombophilia |
| Factor V Leiden mutation |
| Prothrombin G20210A mutation |
| Protein S deficiency |
| Protein C deficiency |
| Antithrombin deficiency |
| Other disorders and risk factors |
| Presence of a central venous catheter |
| Malignancy |
| Surgery, especially orthopedic |
| Trauma |
| Immobilization |
| Pregnancy |
| Oral contraceptives |
| Hormone replacement therapy |
| Certain cancer therapies (eg, tamoxifen, thalidomide, lenalidomide, asparaginase) |
| Heart failure |
| Congenital heart disease |
| Antiphospholipid syndrome |
| Older age (≥65 years) |
| Obesity |
| Severe liver disease |
| Myeloproliferative neoplasms |
| Polycythemia vera |
| Essential thrombocythemia |
| Paroxysmal nocturnal hemoglobinuria |
| Inflammatory bowel disease |
| Nephrotic syndrome |
