Fucosylation of macromolecules is defective in leukocyte-adhesion deficiency II
Fucosylation of macromolecules is defective in leukocyte-adhesion deficiency II
The biochemical abnormality in leukocyte-adhesion deficiency (LAD) II is a general defect in fucosylation of macromolecules. More specifically, it resides at the stage of transport of fucose to the Golgi apparatus.
GDP: guanosine diphosphate; FX-protein: human GDP-I fucose synthase; LAD II: leukocyte-adhesion deficiency type II.
