Graph showing effect of dietary protein restriction on progression of nondiabetic chronic kidney disease

Cumulative fall in GFR over three years in patients with nondiabetic chronic renal failure (mean baseline GFR 39 mL/min) receiving a normal (solid line) and low protein (dashed line) diet. Protein restriction had little or no overall beneficial effect. There was a trend toward more rapid loss of GFR in the first four months followed by a modest slowing of progression during the last 32 months.